Shi Q, Pu CQ, Wu WP, Huang XS, Yu SY, Tian CL, Cao XT
[The determination of medical reference values for tumor markers in cerebrospinal fluid.] [English Abstract, Journal Article]
Zhonghua Yi Xue Za Zhi 2009 Feb 10; 89(5):355-6.
OBJECTIVE: To determine medical reference values for tumor markers in cerebrospinal fluid.
METHODS: Concentrations of CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP, NSE, SCC and HCG were determined by means of double-antibody sandwich ELISA in 110 patients excluding primary tumors and meningeal carcinomatosis using Roche E170 modular immunoassay analyzer.
RESULTS: The determined medical reference values for tumor biomarkers in cerebrospinal fluid were as follows: CEA < 0.573 microg/L, CA125 < 2.591 U/ml, CA15-3 < 2.045 U/ml, CA19-9 < 2.272 U/ml, CA72-4 < 1.252 U/ml, CYFRA21-1 < 1.44 ng/ml, AFP < 0.968 microg/L, NSE < 57.666 ng/ml, SCC < 0.5 microg/L, HCG < 0.769 U/L. There was no correlation between any tumor marker and age (P > 0.05). Concentrations of tumor markers were not affected by gender (P > 0.05).
CONCLUSION: Medical reference values for CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, AFP, NSE, SCC and HCG in cerebrospinal fluid were first determined.
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